Precision imaging in gynecologic cancer

Gynecologic cancers have characteristic structural and functional imaging features reflected in clinical phenotypes, and these imaging biomarkers highlight pathogenic mechanisms potentially targetable by novel treatments. The challenge is now to integrate these imaging biomarkers into clinically relevant treatment algorithms by identifying molecular targets for treatment based on imaging biomarker profiles. Our multidisciplinary research team with competency in computer science, visualization and machine learning algorithms, diagnostic radiology, clinical gynecology, preclinical models and molecular biology/genetics will join efforts to pursue these challenges as one of the funded projects within Centre for Medical Imaging and Visualization in Bergen.

PI: Professor Ingfrid Haldorsen

Molecular and imaging biomarkers in gynecologic cancer will be studied in patients and in preclinical gynecologic cancer models (Figure). Potential imaging biomarkers will be identified using machine learning algorithms applied to multiparametric and functional magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT) from patients and in mouse models during therapy. Furthermore, the molecular and genetic alterations in the tumors as well as clinical phenotype and survival will be studied in relation to the corresponding imaging biomarker profile using integrative analyses. This research initiative provides a unique platform for identifying promising molecular targets for treatment and their corresponding imaging biomarker profiles. Studying imaging biomarkers in mice during targeted therapy will also facilitate the integration of imaging biomarker guided treatment algorithms and imaging guided monitoring of treatment response in gynecologic cancer. This project has the potential to improve patient care by enabling individualized and targeted treatment in gynecologic cancer patients.

Group Members

Senior Researchers

Prof. Antonella Munthe-Kaas

Professor in Mathematics, UiB

Prof. Camilla Krakstad

Professor in Clinical Sciences, UiB
 Bergen Gynecologic Cancer Research Group Leader

Erling Andre Høivik

Dept. of Clinical Sciences

Erlend Hodneland, MSc, PhD

CMR

Veronica Solteszova, MSc, PhD

CMR

PostDocs

Havjin Jacob, MSc, PhD

Heidi Espedal, MSc, PhD

PhD Students

Sigmund Ytre-Hauge, MD

Kristine E Fasmer, MSc

Julie Dybvik, MD

Njål Lura, MD

Geir Kjetil Nilsen, MSc

Hildegunn Aase, MD

Kari Strøno Wagner-Larsen, MD

Research Students

Agnes Jørgensen Eide

Related Publications

 

2019

  • C. Reijnen, J. IntHout, L. F. Massuger, F. Strobbe, H. V. Küsters-Vandevelde, I. S. Haldorsen, M. P. Snijders, and J. M. Pijnenborg, “Diagnostic Accuracy of Clinical Biomarkers for Preoperative Prediction of Lymph Node Metastasis in Endometrial Carcinoma: A Systematic Review and Meta-Analysis,” The Oncologist 2019, 2019. doi:10.1634/theoncologist.2019-0117
    [BibTeX] [Download PDF]
    @article{reijnen2019diagnostic,
      title={Diagnostic Accuracy of Clinical Biomarkers for Preoperative Prediction of Lymph Node Metastasis in Endometrial Carcinoma: A Systematic Review and Meta-Analysis},
      author={Reijnen, Casper and IntHout, Joanna and Massuger, Leon FAG and Strobbe, Fleur and K{\"u}sters-Vandevelde, Heidi VN and Haldorsen, Ingfrid S and Snijders, Marc PLM and Pijnenborg, Johanna MA},
      journal={The Oncologist 2019},
      year={2019},
      publisher={AlphaMed Press},
      doi="10.1634/theoncologist.2019-0117",
      url = "http://theoncologist.alphamedpress.org/content/early/2019/06/11/theoncologist.2019-0117.short"
    }

  • I. S. Haldorsen, N. Lura, J. Blaakær, D. Fischerova, and H. M. J. Werner, “What Is the Role of Imaging at Primary Diagnostic Work-Up in Uterine Cervical Cancer?,” Current Oncology Reports, vol. 21, iss. 9, p. 77, 2019. doi:10.1007/s11912-019-0824-0
    [BibTeX] [Download PDF]
    @Article{Haldorsen2019,
    author="Haldorsen, Ingfrid S.
    and Lura, Nj{\aa}l
    and Blaak{\ae}r, Jan
    and Fischerova, Daniela
    and Werner, Henrica M. J.",
    title="What Is the Role of Imaging at Primary Diagnostic Work-Up in Uterine Cervical Cancer?",
    journal="Current Oncology Reports",
    year="2019",
    month="Jul",
    day="29",
    volume="21",
    number="9",
    pages="77",
    issn="1534-6269",
    doi="10.1007/s11912-019-0824-0",
    url="https://link.springer.com/article/10.1007%2Fs11912-019-0824-0"
    }

  • W. J. van Weelden, K. E. Fasmer, I. L. Tangen, J. IntHout, K. Abbink, A. E. van Herwaarden, C. Krakstad, L. F. Massuger, I. S. Haldorsen, and J. M. Pijnenborg, “Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study,” BMC Cancer, vol. 19, iss. 1, p. 547, 2019. doi:10.1186/s12885-019-5770-6
    [BibTeX] [Download PDF]
    @article{van2019impact,
      title={Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study},
      author={van Weelden, Willem Jan and Fasmer, Kristine Eldevik and Tangen, Ingvild L and IntHout, Joanna and Abbink, Karin and van Herwaarden, Antionius E and Krakstad, Camilla and Massuger, Leon FAG and Haldorsen, Ingfrid S and Pijnenborg, Johanna MA},
      journal={BMC Cancer},
      volume={19},
      number={1},
      pages={547},
      year={2019},
      publisher={BioMed Central},
      doi = {10.1186/s12885-019-5770-6},
      url = {https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5770-6}
    }

  • C. Reijnen, W. J. van Weelden, M. S. Arts, J. P. Peters, P. F. Rijken, K. Van de Vijver, M. Santacana, P. Bronsert, J. Bulten, M. Hirschfeld, E. Colas, A. Gil-Moreno, A. Reques, G. Mancebo, C. Krakstad, J. Trovik, I. S. Haldorsen, J. Huvila, M. Koskas, V. Weinberger, L. Minar, E. Jandakova, M. P. L. M. Snijders, S. van den Berg-van Erp, H. V. N. Kusters-Vandevelde, X. Matias-Guiu, F. Amant, ENITEC-consortium, L. F. A. G. Massuger, J. Bussink, and J. M. A. Pijnenborg, “Poor outcome in hypoxic endometrial carcinoma is related to vascular density,” British journal of cancer, vol. 120, iss. 11, p. 1037, 2019. doi:10.1038/s41416-019-0461-2
    [BibTeX] [Download PDF]
    @article{reijnen2019poor,
      title={Poor outcome in hypoxic endometrial carcinoma is related to vascular density},
      author={Reijnen, Casper and van Weelden, Willem Jan and Arts, Martijn SJP and Peters, Johan P and Rijken, Paul F and Van de Vijver, Koen and Santacana, Maria and Bronsert, Peter and Bulten, Johan and Hirschfeld, Marc and Colas, Eva and Gil-Moreno, Antonio and Reques, Armando and Mancebo, Gemma and Krakstad, Camilla and Trovik, Jone and Haldorsen, Ingfrid S. and Huvila, Jutta and Koskas, Martin and Weinberger, Vit and Minar, Lubos and Jandakova, Eva and Snijders,  Marc P. L. M. and van den Berg-van Erp,  Saskia and Kusters-Vandevelde,  Heidi V. N. and Matias-Guiu, Xavier and Amant,  Frederic and ENITEC-consortium and Massuger, Leon F. A. G.  and Bussink, Johan and Pijnenborg, Johanna M. A. },
      journal={British journal of cancer},
      volume={120},
      number={11},
      pages={1037},
      year={2019},
      publisher={Nature Publishing Group},
        url = "https://www.ncbi.nlm.nih.gov/pubmed/31011231",
      doi = "10.1038/s41416-019-0461-2"
    }

  • S. Hofvind, Å. S. Holen, H. S. Aase, N. Houssami, S. Sebuødegård, T. A. Moger, I. S. Haldorsen, and L. A. Akslen, “Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial,” The Lancet Oncology, vol. 20, iss. 6, pp. 795-805, 2019. doi:10.1016/S1470-2045(19)30161-5
    [BibTeX] [Download PDF]
    @article{hofvind2019two,
      title={Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial},
      author={Hofvind, Solveig and Holen, {\AA}sne S and Aase, Hildegunn S and Houssami, Nehmat and Sebu{\o}deg{\aa}rd, Sofie and Moger, Tron A and Haldorsen, Ingfrid S and Akslen, Lars A},
      journal={The Lancet Oncology},
      volume={20},
      number={6},
      pages={795--805},
      year={2019},
      publisher={Elsevier},
      url = "https://www.ncbi.nlm.nih.gov/pubmed/31078459",
      doi = "10.1016/S1470-2045(19)30161-5"
    }

  • H. S. Aase, Å. S. Holen, K. Pedersen, N. Houssami, I. S. Haldorsen, S. Sebuødegård, B. Hanestad, and S. Hofvind, “A randomized controlled trial of digital breast tomosynthesis versus digital mammography in population-based screening in Bergen: interim analysis of performance indicators from the To-Be trial,” European radiology, vol. 29, iss. 3, pp. 1175-1186, 2019. doi:10.1007/s00330-018-5690-x
    [BibTeX] [Download PDF]
    @article{aase2019randomized,
      title={A randomized controlled trial of digital breast tomosynthesis versus digital mammography in population-based screening in Bergen: interim analysis of performance indicators from the To-Be trial},
      author={Aase, Hildegunn S and Holen, {\AA}sne S and Pedersen, Kristin and Houssami, Nehmat and Haldorsen, Ingfrid S and Sebu{{\o{}}}deg{\aa}rd, Sofie and Hanestad, Berit and Hofvind, Solveig},
      journal={European radiology},
      volume={29},
      number={3},
      pages={1175--1186},
      year={2019},
      publisher={Springer},
      doi = "10.1007/s00330-018-5690-x",
      url = {https://link.springer.com/article/10.1007%2Fs00330-018-5690-x}
    }

  • H. Engerud, K. Hope, H. F. Berg, K. E. Fasmer, I. L. Tangen, I. S. Haldorsen, J. Trovik, and C. Krakstad, “Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer,” PloS one, vol. 14, iss. 1, p. e0210585, 2019. doi:10.1371/journal.pone.0210585
    [BibTeX] [Download PDF]
    @article{engerud2019plasma,
      title={Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer},
      author={Engerud, Hilde and Hope, Kirsten and Berg, Hege Fredriksen and Fasmer, Kristine Eldevik and Tangen, Ingvild L{\o}berg and Haldorsen, Ingfrid Salvesen and Trovik, Jone and Krakstad, Camilla},
      journal={PloS one},
      volume={14},
      number={1},
      pages={e0210585},
      year={2019},
      publisher={Public Library of Science},
      url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333370/},
      doi = "10.1371/journal.pone.0210585"
    }

2018

  • I. L. Tangen, K. E. Fasmer, G. F. Konings, A. Jochems, B. Delvoux, S. Xanthoulea, T. Stokowy, E. Strand, H. F. Berg, S. Auriola, J. Trovik, M. R. Häkkinen, and I. S. Haldorsen, “Blood steroids are associated with prognosis and fat distribution in endometrial cancer,” Gynecologic oncology, 2018. doi:10.1016/j.ygyno.2018.10.024
    [BibTeX] [Download PDF]
    @article{tangen2018blood,
      title={Blood steroids are associated with prognosis and fat distribution in endometrial cancer},
      author={Tangen, Ingvild L and Fasmer, Kristine E and Konings, Gonda F and Jochems, Arthur and Delvoux, Bert and Xanthoulea, Sofia and Stokowy, Tomasz and Strand, Elin and Berg, Hege F and Auriola, Seppo and Trovik, Jone and H{\"a}kkinen, Merja R and Haldorsen, Ingfrid S},
      journal={Gynecologic oncology},
      year={2018},
      publisher={Elsevier},
      url = {https://www.sciencedirect.com/science/article/pii/S0090825818313076?dgcid=coauthor},
      doi = "10.1016/j.ygyno.2018.10.024"
    }

  • V. R. Bollineni, S. Ytre-Hauge, A. Gulati, M. K. Halle, K. Woie, Ø. Salvesen, J. Trovik, C. Krakstad, and I. S. Haldorsen, “The prognostic value of preoperative FDG-PET/CT metabolic parameters in cervical cancer patients,” European Journal of Hybrid Imaging, vol. 2, iss. 1, p. 24, 2018. doi:10.1186/s41824-018-0042-2
    [BibTeX] [Download PDF]
    @article{bollineni2018prognostic,
      title={The prognostic value of preoperative {FDG-PET/CT} metabolic parameters in cervical cancer patients},
      author={Bollineni, Vikram Rao and Ytre-Hauge, Sigmund and Gulati, Ankush and Halle, Mari K and Woie, Kathrine and Salvesen, {{\O}}yvind and Trovik, Jone and Krakstad, Camilla and Haldorsen, Ingfrid S},
      journal={European Journal of Hybrid Imaging},
      volume={2},
      number={1},
      pages={24},
      year={2018},
      publisher={Springer},
      url = {https://ejhi.springeropen.com/articles/10.1186/s41824-018-0042-2},
      doi = "10.1186/s41824-018-0042-2"
    }

  • S. Ytre-Hauge, J. A. Dybvik, A. Lundervold, Ø. O. Salvesen, C. Krakstad, K. E. Fasmer, H. M. Werner, B. Ganeshan, E. Høivik, L. Bjørge, J. Trovik, and I. Haldorsen, “Preoperative tumor texture analysis on MRI predicts high-risk disease and reduced survival in endometrial cancer,” Journal of Magnetic Resonance Imaging, vol. 48, iss. 6, pp. 1637-1647, 2018. doi:10.1002/jmri.26184
    [BibTeX] [Download PDF]
    @article{ytre2018preoperative,
      title={Preoperative tumor texture analysis on MRI predicts high-risk disease and reduced survival in endometrial cancer},
      author={Ytre-Hauge, Sigmund and Dybvik, Julie A and Lundervold, Arvid and Salvesen, {{\O}}yvind O and Krakstad, Camilla and Fasmer, Kristine E and Werner, Henrica M and Ganeshan, Balaji and H{{\o{}}}ivik, Erling and Bj\orge, Line and Trovik, J and Haldorsen, IS},
      journal={Journal of Magnetic Resonance Imaging},
      volume={48},
      number={6},
      pages={1637--1647},
      year={2018},
      publisher={Wiley Online Library},
      url = {https://www.ncbi.nlm.nih.gov/pubmed/30102441},
      doi = "10.1002/jmri.26184"
    }

  • J. B. Frøkjær, F. Akisik, A. Farooq, B. Akpinar, A. Dasyam, A. M. Drewes, I. S. Haldorsen, G. Morana, J. P. Neoptolemos, S. S. Olesen, M. Petrone, A. Sheel, T. Shimosoegawa, and D. Whitcomb, “Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis,” Pancreatology, vol. 18, iss. 7, pp. 764-773, 2018. doi:10.1016/j.pan.2018.08.012
    [BibTeX] [Download PDF]
    @article{frokjaer2018guidelines,
      title={Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis},
      author={Fr{{\o{}}}kj{\ae}r, Jens Br{{\o{}}}ndum and Akisik, Fatih and Farooq, Ammad and Akpinar, Burcu and Dasyam, Anil and Drewes, Asbj{{\o{}}}rn Mohr and Haldorsen, Ingfrid S and Morana, Giovanni and Neoptolemos, John P and Olesen, S{{\o{}}}ren Schou and Petrone, MC and Sheel, A and Shimosoegawa, T and Whitcomb, DC},
      journal={Pancreatology},
      volume={18},
      number={7},
      pages={764--773},
      year={2018},
      publisher={Elsevier},
      url = {https://www.sciencedirect.com/science/article/pii/S1424390318306628?via%3Dihub},
      doi = "10.1016/j.pan.2018.08.012"
    }

  • G. Konings, N. Saarinen, B. Delvoux, L. Kooreman, P. Koskimies, C. Krakstad, K. Fasmer, I. Haldorsen, A. Zaffagnini, M. Häkkinen, S. Auriola, L. Dubois, N. Lieuwes, F. Verhaegen, L. Schyns, R. Kruitwagen, E. Consortium, S. Xanthoulea, and R. A, “Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure,” International journal of molecular sciences, vol. 19, iss. 9, p. 2547, 2018. doi:10.3390/ijms19092547
    [BibTeX] [Download PDF]
    @article{konings2018development,
      title={Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure},
      author={Konings, Gonda and Saarinen, Niina and Delvoux, Bert and Kooreman, Loes and Koskimies, Pasi and Krakstad, Camilla and Fasmer, Kristine and Haldorsen, Ingfrid and Zaffagnini, Amina and H{\"a}kkinen, Merja and Auriola, S and Dubois, L and Lieuwes, N and Verhaegen, F and Schyns, LE and Kruitwagen, RF and ENITEC Consortium and Xanthoulea, S and Romano A},
      journal={International journal of molecular sciences},
      volume={19},
      number={9},
      pages={2547},
      year={2018},
      publisher={Multidisciplinary Digital Publishing Institute},
      url = {https://www.mdpi.com/1422-0067/19/9/2547},
      doi = "10.3390/ijms19092547"
    }

  • T. Engjom, G. Kavaliauskiene, E. Tjora, F. Erchinger, G. Wathle, B. N. Lærum, R. Pål. Njølstad, F. J. Brøndum, O. H. Gilja, G. Dimcevski, and I. S. Haldorsen, “Sonographic pancreas echogenicity in cystic fibrosis compared to exocrine pancreatic function and pancreas fat content at Dixon-MRI,” PloS one, vol. 13, iss. 7, p. e0201019, 2018. doi:10.1371/journal.pone.0201019
    [BibTeX] [Download PDF]
    @article{engjom2018sonographic,
      title={Sonographic pancreas echogenicity in cystic fibrosis compared to exocrine pancreatic function and pancreas fat content at Dixon-MRI},
      author={Engjom, Trond and Kavaliauskiene, Giedre and Tjora, Erling and Erchinger, Friedemann and Wathle, Gaute and L{\ae}rum, Birger Norderud and Nj{{\o{}}}lstad, P{\aa}l Rasmus and Fr{{\o{}}}kj{\ae}r Jens Br{{\o{}}}ndum and Gilja, Odd Helge and Dimcevski, Georg and Haldorsen, Ingfrid S},
      journal={PloS one},
      volume={13},
      number={7},
      pages={e0201019},
      year={2018},
      publisher={Public Library of Science},
      url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062060/},
      doi = "10.1371/journal.pone.0201019"
    }

  • T. Fonnes, J. Trovik, P. Edqvist, K. E. Fasmer, J. Marcickiewicz, S. Tingulstad, A. C. Staff, L. Bjørge, F. Amant, I. S. Haldorsen, H. Werner, L. Akslen, Tangen IL, and C. Krakstad, “Asparaginase-like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study,” BJOG: An International Journal of Obstetrics & Gynaecology, vol. 125, iss. 13, pp. 1695-1703, 2018. doi:10.1111/1471-0528.15403
    [BibTeX] [Download PDF]
    @article{fonnes2018asparaginase,
      title={Asparaginase-like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study},
      author={Fonnes, Tina and Trovik, Jone and Edqvist, P-HD and Fasmer, Kristine E and Marcickiewicz, Janusz and Tingulstad, Solveig and Staff, Anne C and Bj{{\o{}}}rge, Line and Amant, Frederic and Haldorsen, Ingfrid S and Werner, H and Akslen, LA and Tangen, IL, and Krakstad, C},
      journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
      volume={125},
      number={13},
      pages={1695--1703},
      year={2018},
      publisher={Wiley Online Library},
      url = {https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/1471-0528.15403},
      doi = "10.1111/1471-0528.15403"
    }

  • K. Fuglsang, I. S. Haldorsen, E. A. Lundqvist, G. Lindahl, H. Roed, K. Woie, P. Pakarinen, A. Thoroddsen, M. Anttila, and J. Blaakær, “Cervical cancer staging, pretreatment planning and surgical treatment in the Nordic countries–survey from the Surgical Subcommittee of the Nordic Society of Gynecological Oncology,” Acta Obstetricia et Gynecologica Scandinavica, 2018. doi:10.1111/aogs.13388
    [BibTeX] [Download PDF]
    @article{fuglsang2018cervical,
      title={Cervical cancer staging, pretreatment planning and surgical treatment in the Nordic countries--survey from the Surgical Subcommittee of the Nordic Society of Gynecological Oncology},
      author={Fuglsang, Katrine and Haldorsen, Ingfrid S and Lundqvist, Elisabeth Avall and Lindahl, Gabriel and Roed, Henrik and Woie, Kathrine and Pakarinen, P{\"a}ivi and Thoroddsen, Asgeir and Anttila, Maarit and Blaak{\ae}r, Jan},
      journal={Acta Obstetricia et Gynecologica Scandinavica},
      year={2018},
      publisher={Wiley Online Library},
      url = {https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/aogs.13388},
      doi = "10.1111/aogs.13388"
    }

  • T. Engjom, K. D. Pham, F. Erchinger, I. S. Haldorsen, O. H. Gilja, G. Dimcevski, and R. F. Havre, “Good Agreement Between Transabdominal and Endoscopic Ultrasound of the Pancreas in Chronic Pancreatitis,” Ultraschall in der Medizin-European Journal of Ultrasound, 2018. doi:10.1055/a-0583-8254
    [BibTeX] [Download PDF]
    @article{engjom2018good,
      title={Good Agreement Between Transabdominal and Endoscopic Ultrasound of the Pancreas in Chronic Pancreatitis},
      author={Engjom, Trond and Pham, Khahn Do-Chong and Erchinger, Friedemann and Haldorsen, Ingfrid Salvesen and Gilja, Odd Helge and Dimcevski, Georg and Havre, Roald Flesland},
      journal={Ultraschall in der Medizin-European Journal of Ultrasound},
      year={2018},
      publisher={Georg Thieme Verlag KG},
      url = {https://www.thieme-connect.com/DOI/DOI?10.1055/a-0583-8254},
      doi = "10.1055/a-0583-8254"
    }

  • K. E. Fasmer, A. Bjørnerud, S. Ytre-Hauge, R. Grüner, I. L. Tangen, H. M. Werner, L. Bjørge, Ø. O. Salvesen, J. Trovik, C. Krakstad, and I. Haldorsen, “Preoperative quantitative dynamic contrast-enhanced MRI and diffusion-weighted imaging predict aggressive disease in endometrial cancer,” Acta Radiologica, vol. 59, iss. 8, pp. 1010-1017, 2018. doi:10.1177/0284185117740932
    [BibTeX] [Download PDF]
    @article{fasmer2018preoperative,
      title={Preoperative quantitative dynamic contrast-enhanced MRI and diffusion-weighted imaging predict aggressive disease in endometrial cancer},
      author={Fasmer, Kristine E and Bj{{\o{}}}rnerud, Atle and Ytre-Hauge, Sigmund and Gr{\"u}ner, Renate and Tangen, Ingvild L and Werner, Henrica MJ and Bj{{\o{}}}rge, Line and Salvesen, {{\O}}yvind O and Trovik, Jone and Krakstad, Camilla and Haldorsen, IS},
      journal={Acta Radiologica},
      volume={59},
      number={8},
      pages={1010--1017},
      year={2018},
      publisher={SAGE Publications Sage UK: London, England},
      url = {http://journals.sagepub.com/doi/pdf/10.1177/0284185117740932},
      doi = "10.1177/0284185117740932"
    }

  • T. Engjom, E. Tjora, G. Wathle, F. Erchinger, B. N. Lærum, O. H. Gilja, I. S. Haldorsen, and G. Dimcevski, “Secretin-stimulated ultrasound estimation of pancreatic secretion in cystic fibrosis validated by magnetic resonance imaging,” European radiology, vol. 28, iss. 4, pp. 1495-1503, 2018. doi:10.1007/s00330-017-5115-2
    [BibTeX] [Download PDF]
    @article{engjom2018secretin,
      title={Secretin-stimulated ultrasound estimation of pancreatic secretion in cystic fibrosis validated by magnetic resonance imaging},
      author={Engjom, Trond and Tjora, Erling and Wathle, Gaute and Erchinger, Friedemann and L{\ae}rum, Birger N and Gilja, Odd H and Haldorsen, Ingfrid Salvesen and Dimcevski, Georg},
      journal={European radiology},
      volume={28},
      number={4},
      pages={1495--1503},
      year={2018},
      publisher={Springer},
      url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834563/pdf/330_2017_Article_5115.pdf},
      doi = "10.1007/s00330-017-5115-2"
    }

  • S. Ytre-Hauge, M. Esmaeili, T. E. Sjøbakk, R. Grüner, K. Woie, H. M. Werner, C. Krakstad, L. Bjørge, Ø. O. Salvesen, I. M. Stefansson, J. Trovik, B. TF, and I. Haldorsen, “In vivo MR spectroscopy predicts high tumor grade in endometrial cancer,” Acta Radiologica, vol. 59, iss. 4, pp. 497-505, 2018. doi:10.1177/0284185117733297
    [BibTeX] [Download PDF]
    @article{ytre2018vivo,
      title={In vivo MR spectroscopy predicts high tumor grade in endometrial cancer},
      author={Ytre-Hauge, Sigmund and Esmaeili, Morteza and Sj{{\o{}}}bakk, Torill E and Gr{\"u}ner, Renate and Woie, Kathrine and Werner, Henrica M and Krakstad, Camilla and Bj{{\o{}}}rge, Line and Salvesen, {{\O}}yvind O and Stefansson, Ingunn M and Trovik, J and Bathen. TF and Haldorsen, IS},
      journal={Acta Radiologica},
      volume={59},
      number={4},
      pages={497--505},
      year={2018},
      publisher={SAGE Publications Sage UK: London, England},
      url = {http://journals.sagepub.com/doi/pdf/10.1177/0284185117733297},
      doi = "10.1177/0284185117733297"
    }